NanoString Technologies, Inc, a leading provider of life science tools for discovery and translational research, announced the release of the first public dataset of the whole transcriptome obtained at true single-cell resolution on the CosMx Spatial Molecular Imager (SMI). The data will be highlighted at the 42nd annual J.P.
CosMx Whole Transcriptome Panel Achieves Scientific Moonshot
NanoString is the first company to achieve the scientific breakthrough of providing true single-cell whole transcriptome imaging. This technological milestone was accomplished using the CosMx SMI platform allowing researchers to simultaneously visualize the expression of every protein-coding gene in the human genome in situ, providing the ultimate capability for single cell spatial biology.
The CosMx Whole Transcriptome Panel transforms the potential to extract biological insights from formalin-fixed paraffin-embedded (FFPE) tissue samples. By imaging the expression of almost 19,000 genes at once, this product will provide almost 40x the coverage of assays currently marketed by competing platforms. Researchers can now explore millions of cells per experiment, identify rare cell types, and understand cell-to-cell interactions in spatial context, providing a comprehensive understanding of cellular landscapes that has never before been accessible. These capabilities will be available at lower cost per single cell while providing higher cellular throughput than traditional single cell RNA sequencing (scRNA-seq). NanoString plans to commercially launch the CosMx Whole Transcriptome Panel in 2025.
NanoString is marking this milestone achievement with the public release of a whole transcriptome CosMx SMI dataset generated from FFPE samples of healthy human pancreas tissue. This first-of-its-kind dataset demonstrates the functional biology of the pancreas revealing rare cell types that are typically lost with traditional scRNA-seq methods. This dataset was generated using a prototype version of the panel and related software, and the performance of the new capability is expected to improve in the full commercial version, becoming even more impressive over time.
“Using the CosMx Whole Transcriptome Panel, our group can now address fundamental questions regarding the interactions between anatomy and function within pancreatic islets that are simply not possible with lower plex (< 1000-plex) imaging technologies,” said Grant R. Kolar, M.D., Ph.D., Director, Research Microscopy and Histology Core at the Saint Louis University School of Medicine. “We anticipate that this transformative technology will have profound impact on the way we view normal islet physiology, as well as yield important, novel insights into the pathophysiology of diabetes, enabling the development of better treatments, and perhaps even a cure.”
Anticipating intense interest from the scientific community, NanoString will feature the Whole Transcriptome capabilities of CosMx SMI during presentations at the upcoming AGBT meeting in Orlando, Florida, Feb. 5-8, 2024. Customers who have gained access to prototypes of the CosMx Whole Transcriptome Panel will present datasets generated on pancreatic cancer, colorectal cancer, and human brain
SOURCE: Businesswire