Charles River Laboratories International, Inc. and Curigin, a Korean biotechnology company developing innovative oncolytic ribonucleic acid interference (RNAi) gene therapies, announced a collaboration for adenoviral vector production. The gene therapy developer will leverage Charles River’s market-leading expertise in contract development and manufacturing organization (CDMO) solutions to support its preclinical and clinical trials.
Curigin develops anticancer gene therapy products that utilize innovative genetically engineered viruses and novel RNAi technology to quickly and accurately block key disease-specific genetic signal pathways, effectively switching off genes responsible for tumor growth. These gene therapies serve an unmet clinical need and can be offered to patients who have not been treated with conventional cancer drugs.
Also Read: BioPharmCatalyst Introduces Enhanced Suite of Tools for Biotech Investment Community
Developing a Treatment for Bladder Cancer
Curigin’s lead candidate is CA102, a genetically engineered adenovirus for bladder cancer which, according to the World Cancer Research Fund, is the 10th most common type of cancer worldwide. Based on preclinical evaluation data for CA102, Curigin expects to submit an Investigational New Drug (IND) application to the Food and Drug Administration (FDA) within the year.
Adenoviral Vector Manufacturing Services
Charles River has standardized protocols for cell culture, transfection, and downstream purification, as well as a validated platform process with a proven track record. These high-yield, optimized methods increase speed to clinical manufacturing by reducing process development time and costs while ensuring the highest quality production.
Expanding its comprehensive cell and gene therapy portfolio to span viral vector, plasmid DNA, and cell therapy production, through the acquisitions of Vigene Biosciences, Cobra Biologics, and Cognate BioServices in 2021, Charles River offers end-to-end support and supply chain simplification for gene therapy developers.
SOURCE: Businesswire