Zymo Research Corp, a leading provider of life science technologies, has partnered with Opentrons Labworks, Inc., a leader in lab automation, to revolutionize cell-free DNA isolation and analysis. The collaboration brings an innovative fully automated, comprehensive workflow from sample collection through library preparation transforming liquid biopsy analysis.
Current, common methods of liquid biopsy extraction can be challenging for cancer research due to inefficient recovery of cell-free DNA. The Zymo Research and Opentrons partnership offers a new approach that overcomes the hurdles of these common methods. The combination of Zymo Research’s chemistries with the advanced automation capabilities of the Opentrons Flex platform offers superior cfDNA yields, reduced processing time and consistent data delivery. This new method will revolutionize the efficacy of cfDNA analysis, enabling improvements in clinical cancer research outcomes.
The impactful collaboration will also lead to the development of a complete automated liquid biopsy workflow that enhances the accuracy and sensitivity of the downstream analysis. This unique workflow utilizes the ZymoSeq Cell Free WGBS Library Prep Kit, a fully automatable bisulfite chemistry and clean-up that utilizes prepared cfDNA for methylation analysis by Next Generation Sequencing (NGS).
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“Cell-free DNA plays a pivotal role in non-invasive testing, disease diagnosis and monitoring, personalized medicine, biomarker discovery, and genomic research. Through our collaboration with Opentrons, we aim to automate and streamline liquid biopsy processes, setting new standards in efficiency, accuracy and reproducibility for downstream cfDNA analysis,” said Dr. Marc Van Eden, VP of Business Development at Zymo Research.
“We are excited to collaborate with Zymo Research to advance liquid biopsy workflows through accessible automation. By leveraging Zymo’s technologies and the high-throughput capabilities of the Opentrons Flex platform, we aim to enable scientists to efficiently process a high volume of cell-free DNA samples in an automated manner to support high sensitivity and accurate methylation calling,” said James Atwood, General Manager of Opentrons Robotics.
This collaboration between Zymo Research and Opentrons further solidifies their track record of fruitful partnership. Previous collaborations include the automation of popular Zymo Research chemistries like ZymoBIOMICS™, Quick-DNA™, and Direct-Zol™ on Opentrons’ reliable and affordable personal pipetting robot, the OT-2. With over 20 protocols automating Zymo Research kits contributed by the scientific community, these efforts have expanded the availability of highly qualified protocols available through the Opentrons’ Protocol Library.
SOURCE: PRNewswire