“Molecular testing in thyroid cancer currently focuses primarily on whether a patient’s thyroid nodule is benign or cancerous, and whether specific gene mutations are present,” said Joshua Klopper, M.D., Veracyte’s medical director for Endocrinology. “The data to be presented at ENDO 2024 looks beyond individual gene mutations and explores the potential of novel molecular signatures and alterations to provide more-granular, prognostic information. This may ultimately help clinicians guide more individualized care based on the molecular characteristics of each patient’s tumor. These findings are from studies using Afirma GRID, a research-use-only tool that leverages Veracyte’s whole-transcriptome approach, which enables the scientific community to advance understanding of thyroid cancer biology.”
Following are details for the Afirma GRID-focused research studies that will be presented at ENDO 2024 in the Boston Convention & Exhibition Center:
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Title: |
Retrospective Analysis of mRNA Expression Based Signatures of Thyroid Tumor Invasion and Metastases |
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Presenter: |
Sara Ahmadi, M.D., Brigham and Women’s Hospital |
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Format: |
Poster Presentation (MON-640) |
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Time: |
Monday, June 3, 2024, 12:00 p.m. – 1:30 p.m. ET |
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Location: |
ENDO Expo Poster Area |
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Title: |
Prostate-specific Membrane Antigen (PSMA) Expression in Cytologically Indeterminate and Malignant Thyroid Nodules |
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Presenter: |
Rabail Sadiq, M.B.B.S., Johns Hopkins University School of Medicine |
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Format: |
Rapid-Fire Oral Presentation (RF28-01) AND Poster Presentation (MON-649) |
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Poster Presentation (MON-649): |
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Time: |
Monday, June 3, 2024, 12:00 p.m. – 1:30 p.m. ET |
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Location: |
ENDO Expo Poster Area |
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Rapid-Fire Oral Presentation (RF28-01): |
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Time: |
Monday, June 3, 2024, 1:45 p.m. – 1:50 p.m. ET |
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Location: |
Room 257AB |
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Title: |
Cancer-associated Fibroblasts Correlate with Aggressive Thyroid Cancer Behavior: Insights from Four Large Patient Cohorts |
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Presenter: |
Matthew A. Loberg, B.A., Vanderbilt University Medical Center |
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Format: |
Oral Presentation (OR28-04) |
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Time: |
Monday, June 3, 2024, 2:45 p.m. – 3:00 p.m. ET |
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Location: |
Room 257AB |
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The Afirma GRID database is inclusive of the sequencing of over 21,000 expressed genes for nearly 200,000 patients with thyroid nodules (benign and malignant) and is used by Veracyte and its partners to contribute to continued research that helps advance understanding of thyroid tumors. Afirma GRID information is available on a Research-Use-Only basis.
Veracyte’s flagship Afirma Genomic Sequencing Classifier (GSC) was developed with RNA whole-transcriptome-derived sequencing and machine learning technology and helps physicians identify patients with benign thyroid nodules among those whose fine needle aspiration (FNA) biopsy results are indeterminate by cytopathology so that they can potentially avoid unnecessary thyroid surgery. The Afirma GSC also includes Xpression Atlas, the largest thyroid gene and fusion variant panel available, to help inform treatment decisions for patients whose genomic test or cytopathology results are suspicious for cancer.
Veracyte is a global diagnostics company whose vision is to transform cancer care for patients all over the world. We empower clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer. Our Veracyte Diagnostics Platform delivers high-performing cancer tests that are fueled by broad genomic and clinical data, deep bioinformatic and AI capabilities, and a powerful evidence-generation engine, which ultimately drives durable reimbursement and guideline inclusion for our tests, along with new insights to support continued innovation and pipeline development.
SOURCE: Businesswire