Canopy, the first Continuous Care Platform for oncology, announced platform-wide support for bispecific antibodies. This support includes Remote Therapeutic Monitoring, smart triage algorithms, and decision-support pathways for CRS and ICANs.
Bispecific antibodies (BsAbs) are a next-generation advancement in monoclonal antibody (mAb) therapy. By simultaneously targeting two antigens or epitopes, they can elicit multiple physiological or anti-tumor responses, acting like a “cocktail” of two mAbs. This dual-targeting approach produces significant treatment effects. With 10 BsAbs already approved across both solid tumors and hematologic cancers—including the recent approval in non-small cell lung cancer—and over 220 oncology-focused BsAbs currently in development, the adoption of these therapies in community oncology is expected to grow rapidly.1
However, BsAbs bring a combination of novel toxicities and complex management guidelines. These range from common symptoms, such as diarrhea or rash that may be severe and appear at unpredictable times, to dangerous conditions, including Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), or even rare and potentially life-threatening toxicities. As a result, oncology practices face multiple barriers to adoption, especially in the outpatient setting, including the need for specialized protocols and training and the integration of high-frequency remote patient monitoring into clinical operations.
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“Patients receiving these treatments require vigilant monitoring and nuanced management to ensure safety. Canopy’s technology plays a crucial role in keeping patients safe when they’re away from the clinic, especially when administering bispecific antibodies and CAR-T in the outpatient setting,” said James Essell, MD, Medical Director of the Center for Cancer and Cellular Therapy at Oncology Hematology Care (OHC) and The Jewish Hospital, and Chair for Cellular Therapy at Sarah Cannon Research Institute.
With Canopy, practices can seamlessly monitor their patients for BsAbs-induced toxicities, including CRS and ICANS. Smart monitoring schedules check in with patients through digital assessments via app, web, or phone. Canopy’s intelligent triage algorithms allow busy nurses to focus on the patients who need them the most and enable rapid issue resolution with standardized symptom pathways.
“The clinical impact of continuous care models, especially those incorporating ePRO-based monitoring, has been widely demonstrated in oncology, showing significant benefits for patients,” said Michael Kolodziej, MD, Chief Medical Officer of Canopy. “As new therapies like bispecific antibodies become more common, these models are now essential for safely and effectively managing care in the outpatient setting.”
SOURCE: PRNewswire