Twist Bioscience Corporation, a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, and IMIDomics, Inc., a patient-centric drug discovery and development company focused on Immune-Mediated Inflammatory Diseases (IMIDs), announced a multi-program collaboration whereby Twist will utilize its antigen development capabilities and Library of Libraries to conduct antibody discovery activities against targets identified by IMIDomics.
The targets were identified using IMIDomics’ proprietary Clinical Discovery Engine™, a multidimensional, integrated, and data-driven platform for uncovering the underlying mechanisms of IMIDs. Under the terms of the collaboration, Twist will receive an upfront and project specific fees and will be eligible to receive payments associated with specific clinical and commercial milestones as well as royalty payments on product sales. IMIDomics will receive human antibodies against several of its priority targets from Twist.
“This collaboration with IMIDomics brings together expertise in relevant target identification and antibody discovery, two key areas needed for successful drug discovery and development,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “IMIDomics leverages its extensive biobank data to identify targets not previously associated with IMIDs. To discover antibodies that are highly specific to these targets, we will leverage the expertise of our Biopharma Solutions team across sites, utilizing our Twist Boston team for antigen production, which will be used by our team in South San Francisco to discover highly specific human antibody leads for IMIDomics.”
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“A significant percentage of patients with IMIDs don’t respond to existing drugs,” said H. Daniel Perez, M.D., Chief Development Officer of IMIDomics. “We leverage our proprietary Clinical Discovery Engine™ to interrogate multiple layers of biological information to identify targets not previously associated with immune-mediated inflammatory diseases. We are already at work using the discoveries we’ve made to date to develop and validate a robust pipeline of drug candidates for these diseases. Through our multi-program collaboration with Twist, we can continue to build on this work, finding new potential treatments by making this data actionable and leveraging their extensive capabilities in antibody discovery to advance our discovery-stage programs.”
SOURCE: Businesswire